Oral dysbiosis exacerbates the virulence of Candida parapsilosis sensu stricto via up-regulation of the CPH2 biofilm master gene

Candida parapsilosis sensu stricto is the second to third most frequent cause of candidemia. Studies place this yeast as a colonizer niches oral cavity, predominantly in pathological conditions. We hypothesize that buccal environment dysbiosis enhances virulence C. stricto. Objective: To evaluate at phenotype and molecular level production biofilm isolates correlate results with clinical origin (dysbiosis versus eubiosis). Material methods: The biofilm-forming ability was compared 50 obtained from patients without dysbiosis; by quantification biomass metabolic activity. were corroborated optical confocal fluorescence microscopy, correlated transcriptional activity CPH2, RT-qPCR. data analyzed Excel 2010, InfoStat 2018, 95% confidence interval. Results: significantly higher relative control (p = 0.0025). Basal expression CPH2 increased 2.8 times more related condition showed no significant differences pathogenic same yeast, derived onychomycosis lesions. Conclusion: cavity increases due possible changes epigenetic marks. This finding suggests may be an alternative route skin epidemiology nosocomial